The Back Exercises to Neutralize Disability Study

Inclusion Criteria: 1. Men and women aged 18 to 50 years, with no significant health issues or conditions that, in the investigator's opinion, would limit the subject's ability to complete the study per protocol or that would impact the capability to get an accurate measurement of study endpoints. 2. Answer yes to the following question: Have you had two or more episodes of low back pain in the past 12-months with at least one of the episodes causing a restriction of work or leisure time activity? 3. Exhibit low trunk extensor endurance defined as the time to task failure during the modified-Sorenson test of less than 176 seconds. 4. Body mass index (BMI) between 19 and 37 kg/m2 inclusive. 5. With no condition that could limit participation in supervised resistance training exercise based on the Physical Activity Readiness Questionnaire (PAR-Q) (i.e., if a study participant answers yes to questions 1-4 they will be excluded, if they answer yes to 5-7 they will require clearance for participation by the study physician). 6. Sedentary lifestyle defined by a classification of "low" or "moderate" levels of physical activity based on the scoring criteria for the International Physical Activity Questionnaire (IPAQ). 7. Willing to maintain current diet and adhere to exercise programs described for the study and to not start any new dieting/weight management programs. 8. Willing and able to return for all clinic visits and complete all study-related procedures. 9. Able to read, understand, and complete study-related questionnaires 10. Able to read and understand, and willing to sign the informed consent form (ICF). Exclusion Criteria: 1. Participation in progressive resistance exercise within the previous 24 weeks prior to screening. 2. Participation in any clinical trial within 24 weeks prior to screening. 3. Hospitalization (medical confinement for ≥24 hours), or immobilization, or major surgical procedure requiring general anesthesia within 24 weeks prior to screening, or any planned surgical procedures during the study period. 4. Limb amputation (except for toes) and/or any fracture within 24 weeks. 5. Osteoarthritis, rheumatologic diseases or orthopedic disorders which will not allow completion of the motions required for the resistance exercise. 6. Conditions (such as myasthenia gravis, myositis, muscular dystrophy or myopathy, including drug-induced myopathy) leading to muscle loss, muscle weakness, muscle cramps or myalgia. 7. Chronic or relapsing/remitting gastrointestinal disorders such as inflammatory bowel diseases, irritable bowel syndrome or gastrointestinal infections within 28 days of screening. 8. Acute viral or bacterial upper or lower respiratory infection at screening 9. Moderate or severe chronic obstructive pulmonary disease. 10. Back pain greater than 4 (on a 10 point numeric pain rating scale) at screening 11. Leg length discrepancy \> 3 cm. 12. Current or recent (i.e., within 12 weeks) of narcotics or muscle relaxants. 13. Currently pregnant (confirmed via a urine test) or planning to become pregnant within the next year at screening. 14. Report unexplained weight loss over the past 30 days (\> 10 pounds). 15. Report having pending litigation related to low back pain or currently receiving disability for low back pain. 16. Report having received treatment for low back pain from a health care practitioner in the past 6 weeks. 17. History of spine surgery or hip arthroplasty. 18. Cancer requiring treatment currently or in the past 3 years (except primary non-melanoma skin cancer or in situ cervical cancer) 19. Moderate or severe asthma with current or recurring symptoms within the last 1-year. 20. Known history of human immunodeficiency virus (HIV) antibody and/or positive hepatitis B surface antigen (HBsAg) and/or positive hepatitis C antibody (HCV) at screening. 21. Neurological conditions resulting in impaired muscle function or mobility (e.g., stroke with residual paresis, paralysis, multiple sclerosis, or Parkinson Disease). 22. Psychiatric conditions that warrant acute or chronic therapeutic intervention (e.g., major depressive disorder, bipolar disorder, panic disorder, schizophrenia) that in the investigators opinion may interfere with the conduct of study procedures 23. History of cardiac conditions such as heart failure (NYHA class II-IV), angina (including unstable angina), myocardial infarction, cardiomyopathy, any cardiac arrhythmia (except stable sinus dysrhythmia or atrial fibrillation) or valvular heart disease (except asymptomatic mitral valve prolapse). 24. History of peripheral vascular disease. 25. Subjects with the following abnormal ECG findings at screening will be excluded: Electrocardiogram findings indicative of left ventricular hypertrophy (LVH) (based on Cornell voltage criteria): For men: S in V3 plus R in a VL \>2.8 mV (28 mm) For women: S in V3 plus R in a VL \>2.0 mV (20 mm) Electrocardiogram finding of QT prolongation defined as QTcF \> 470 ms 26. Diabetics using insulin are excluded. 27. Abnormal or uncontrolled blood pressure at the screening visit defined as diastolic BP \>100 and/or systolic BP \>160 mm Hg; if taking anti-hypertensive medication, have to be on stable doses of medication for more than 3 months. 28. Current or recent history (within 1 year of screen) of heavy alcohol consumption (males ≥ 21 drinks/week, 4 drinks/day; females ≥ 14 drinks/week, 3 drinks/day) or drug abuse. 29. Current or previous use of any drugs known to influence muscle mass or performance within 24 weeks. These may include, but are not limited to, anabolic steroids, IGF-1, growth hormone (GH), replacement androgen therapy, anti-androgen therapy. 30. Use of systemic glucocorticoids within 12 weeks prior to screening. 31. Having body dimensions that exceed the MRI or exercise equipment limits. 32. Unable to undergo MRI (e. g. body containing any metallic medical devices or equipment, including heart pacemakers, metal prostheses, implants or surgical clips, any prior injury from shrapnel or grinding metal, exposure to metallic dusts, metallic shavings or having tattoos containing metallic dyes). 33. Unable to reliably undergo exercise or strength tests described for this study.