The hypothesis is that a stroke causes release of purines from brain into blood and that this is a very early biomarker of brain ischaemia. The investigators propose a simple blood test of substances (the purines) that result from cellular metabolism and are produced in excess when brain cells are starved of oxygen and glucose (as occurs during a stroke).
In this study, the investigators propose to use newly developed biosensor technology (SMARTCap) to directly address whether purines are indicators of real strokes, and can distinguish strokes from other conditions with similar symptoms, more rapidly.
Study Type
OBSERVATIONAL
Enrollment
217
The Sarissa Biomedical SMARTCap biosensor array. This is an array of biosensors and electrodes in a simple moulded device that will fit into a vacutainer blood tube and will enable the rapid measurement of purines in freshly drawn blood. Therefore, this is not an intervention as such as the device is an In-Vitro Diagnostic Medical Device.
University Hospitals Coventry & Warwickshire NHS Trust
Coventry, United Kingdom
University of Keele
Stoke-on-Trent, United Kingdom
To measure the levels of purine in the blood in Stroke patients compared to non-stroke patients (Healthy controls)
Time frame: 30 minutes down to 5 minutes
To identify ischaemic versus haemorrhagic strokes by combining purine measurements and CT scans
Time frame: 24 hours to 7 days
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