The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

Attikon Hospital20 enrolled

Overview

This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes

Interventions

VinegarDIETARY_SUPPLEMENT

0,50mmol vinegar (6% acetic acid)

PlaceboOTHER

50 ml water

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy 2. Recreationally active 3. With stable body weight and diet during the last two months. Exclusion Criteria: 1. Any systemic disease (besides glucose abnormalities) 2. Any medication therapy 3. Diabetic complications

Outcomes

Primary Outcomes

Muscle glucose uptake following meal ingestion (area under the glucose uptake versus time curve-AUC)