Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension

Actelion

Overview

The objective of the study is to monitor physical activity longitudinally with a wrist activity tracker specifically in PAH patients newly initiating ERA therapy and to assess the correlation with the 6MWD at different time points. Further objectives are to assess the correlation of physical activity measured with the tracker and other parameters for clinical evaluation and right ventricular function assessment (i.e. Biomarkers, WHO Functional class, hospitalization due to PAH, Echochardiography and Quality of Life) as well as sleep efficacy in PAH patients newly initiating ERA therapy.

Study Type

OBSERVATIONAL

Conditions

Pulmonary Arterial Hypertension

Interventions

Endothelin receptor antagonist therapyDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female patients with right heart catheter (RHC)-confirmed PAH (WHO PH group I) * Age ≥18 year * Not receiving ERA therapy in the 30 days prior to the enrolment visit * Signed patient informed consent form Exclusion Criteria: * Patient with conditions that prevent compliance with the protocol or to adhere to therapy and use of the device

Outcomes

Primary Outcomes

Activity score measured with an electronic activity tracker and absolute 6MWD assessed at different time points during ERA treatment