The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. The study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
calf raise exercise
Department for circulation and medical imaging, NTNU
Trondheim, Postboks 8905, Norway
absolute walking distance (meters) as measured by 6 minute walking test
treadmill 3.2 km/hour and inclination increase every 2 minute combined with 6 minute walking test
Time frame: 8 weeks
mitochondrial function measured by respirometry
Oxygen consumption (pmol O2 per second per mg of wet weight tissue) measured by respirometry
Time frame: 8 weeks
Arterial bloodflow measured by plethysmography
measured by plethysmography
Time frame: 8 weeks
Quality of life assessed by SF 36 and CLAU-S questionnaires
assessed by SF 36 and CLAU-S questionnaires
Time frame: 8 weeks
Peak oxygen uptake measured by cardio-pulmonal exercise testing
measured by cardio-pulmonal exercise testing
Time frame: 8 weeks
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