Prospective, Randomized Clinical Trial Comparing Macular Photocoagulation With or Without Intravitreal Bevacizumab or Triamcinolone for the Treatment of Diabetic Macular Edema

Inclusion Criteria: 1. clinically significant diabetic macular edema (DME) with diffuse leakage involving the center of the fovea, with DME greater than 275 microns in OCT examination 2. BCVA between 0.3 LogMAR (logarithm of smaller angle of visual resolution) (20/40) and 1.6 LogMAR (20/800) 3. signed of inform Consent. Exclusion Criteria: 1. HbA1c levels greater than 10% 2. thromboembolic event history (including myocardial infarction and stroke) 3. vitreo-macular traction on OCT 4. coagulation disorders 5. macular ischemia on fluorescein angiography examination 6. proliferative diabetic retinopathy that required treatment 7. eye surgery 8. history of ocular hypertension or glaucoma 9. any ocular pathology which in the opinion of the investigator, could macular edema or change the visual acuity during the study period (for example, retinal vascular occlusion, uveitis or other inflammatory eye disease, neovascular glaucoma) 10. systemic corticosteroid therapy 11. any conditions that could affect the documentation 12. any previous treatment for diabetic macular edema.