Evaluation of the Signaling Path of Emiline1-TGFβ in the Myogenic Tone of Resistance Arteries in a Population of Normotensive and Hypertensive Subjects

Neuromed IRCCS95 enrolled

Overview

Aim of this study is to enhance the knowledge of myogenic tone alterations in hypertensive patients and to better understand the mechanisms controlling the myogenic tone. Evaluations will be performed through ex vivo studies of peripheral arterioles in human adipose tissue from lumbar muscle, isolated from biopsies. This will allow investigators to evaluate the myogenic function in response to progressive blood pressure increases, in order to correlate myogenic function to arterial hypertension and to the molecular mechanisms already identified in the preclinical models.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypertension

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Males or females between 30 and 70 years of age * Hypertensive patients: Patients with a previous diagnosis of hypertension * Normotensive patients: subjects without story of hypertension * Written informed consent Exclusion Criteria: * Severe hypertension (eg, systolic \>180 mm Hg, diastolic \>110 mm Hg) * Manifested or suspected secondary hypertension (coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, pheochromocytoma) * History of cardiac complications (previous acute myocardial infarction (AMI), unstabile angina, percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass grafting (CABG), congestive heart failure (NYHA II-IV)) * Diabetes mellitus * Renal pathologies (creatinine clearance \< 30 ml/min) * Severe hepatic dysfunction

Evaluation of the Signaling Path of Emiline1-TGFβ in the Myogenic Tone of Resistance Arteries in a Population of Normotensive and Hypertensive Subjects

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes