The study purpose is to compare the effect of different Administration Routes of Pediatric Premedication (including oral administration, intramuscular injection, rectal perfusion, intranasal).
In this study, 80 cases of surgical or otolaryngology children undergoing elective surgery were divided into four groups：oral administration group, intramuscular group, rectal infusion group, intranasal group depending on the route of administration before anesthesia. By observing the difference of sedative effects, postoperative recovery, and postoperative psychological behavior among the four groups,compare the effect of four pre-anesthetic administration routes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Premedicate--Oral administration of a mixture at preoperative 30 minutes: ketamine 3 mg/kg, midazolam 0.5 mg/kg and atropine 0.02 mg/kg, plus 50% glucose solution to 0.5ml /kg.
Premedicate--At preoperative 30 minutes intramuscular injection of atropine 0.02 mg/kg, 5 minutes before entering the operation room, intramuscular injection of ketamine 5 mg/kg.
Premedicate--At preoperative 30 minutes rectal infusion of midazolam 0.5mg/kg
Sedation Score
Time frame: Try to break away from family membersan，an expected average of 3 min；Successfully break away from the family members and accept the face mask and venipuncture，an expected average of 5 min
Hemodynamic and anesthetic depth monitoring (Heart rate, blood pressure, pulse oxygen saturation, bispectral index(BIS)
Heart rate, blood pressure, pulse oxygen saturation, bispectral index(BIS)
Time frame: From premedication to 10 min after extubation up to 4 hours
Stress index monitoring (The concentration of Plasma cortisol and blood sugar)
The concentration of Plasma cortisol and blood sugar
Time frame: From anesthesia induction to 10 min after the start of surgery up to 30 min
Postoperation recovery assess (Wake up agitation score (PAED)、Steward score 、Postoperative recovery score)
Wake up agitation score (PAED)、Steward score 、Postoperative recovery score
Time frame: 10 min after extubation
Postoperative behavior assessment (Postoperative behavior scale (PHBQ)
Postoperative behavior scale (PHBQ)
Time frame: 1 day after the operation，7 day after the operation
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Premedicate--At preoperative 30 minutes dripping nose of Imidazole valium 0.2 mg/kg
After entering the operation room ,all cases intravenous midazolam 0.05 mg/kg, fentanyl 3μg/kg, closed-loop target controlled infusion propofol and atracurium .
Intubation when the trachea-oesophageal fistula（TOF） value fell 15%, BIS value dropped to 40.
All cases intravenous midazolam 0.05 mg/kg, fentanyl 3μg/kg, closed-loop target controlled infusion propofol and atracurium .