Optimizing Psoriasis Treatment of Etanercept Combined Methotrexate

Inclusion Criteria: * Adults of both sexes, at least 18 years of age * have stable plaque psoriasis for at least 6 months, psoriasis involving at least 10 percent of the body surface area, had a minimal PASI of 10 at screening * had previously received phototherapy or systemic psoriasis therapy at least once or candidates for such therapy in the opinion of the investigator Exclusion Criteria: * Patients with guttate, erythrodermic, or pustular psoriasis at the time of screening * recent infection or opportunistic infections, active tuberculosis, hepatitis B and so on * liver and kidney dysfunction * those with other serious, progressive, uncontrolled disorders of vital organs and systems (including cardiovascular, liver, lung and kidney), other autoimmune diseases, cancer, HIV infection, which are not suitable for participation in the study of the disease * history of significant methotrexate toxicity or total cumulative methotrexate exposure \> 1000 mg (unless grade ‡ IIIb liver injury has not occurred) * use of ultraviolet (UV) B therapy, topical ciclosporin or calcineurin inhibitors, class III through VII topical corticosteroids (permitted on the scalp, axillae, and ⁄or groin), or topical vitamin A or D analogues within 14 days of screening * and psoralen or UVA therapy, systemic psoriasis therapy (including methotrexate), oral retinoids, class I or II topical corticosteroids, dithranol, cyclophosphamide, sulfasalazine, or intravenous or oral calcineurin inhibitors within 28 days of screening * Patients were excluded if they had received a tumor necrosis factor (TNF) blocking agent or other biologics within 3 months or interleukin (IL)-12 or IL-23 inhibitors within 6 months of study initiation