Daily Protein Intake Distribution and MPS (ARCIII)

Société des Produits Nestlé (SPN)20 enrolled

Overview

To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Overweight

Interventions

whey proteinOTHER

whey protein.

placeboOTHER

placebo.

Eligibility

Sex: MALEMin age: 60 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Overweight/obese (BMI 27-40 kg/m2) * Non-smokers * Non-diabetic * No history of hyperlipidemia * Not taking medications thought to interfere with study * Considered generally healthy Exclusion Criteria: * Efforts to lose weight in previous 16 weeks * Hyperlipidemia * Blood pressure ≥ 140/90 mmHg * Smoking * Heart and other organ disease * Type 2 diabetes * Gastrointestinal disease * Orthopedic injury interfering with exercise * Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)

Outcomes

Primary Outcomes

muscle protein synthesis

protein synthesis is evaluated in muscle biopsy tissue

Time frame: up to 4 weeks

Secondary Outcomes

body composition is evaluated using DEXA

Time frame: up to 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.