Protein Nutrition for Muscle Hypertrophy in Older Adults

Société des Produits Nestlé (SPN)30 enrolled

Overview

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy Elderly Muscle Anabolically Resistant Elderly Muscle

Interventions

isolated whey proteinDIETARY_SUPPLEMENT

isolated whey protein

micellar whey proteinDIETARY_SUPPLEMENT

micellar whey protein

glycineDIETARY_SUPPLEMENT

glycine

citrulline

Eligibility

Sex: MALEMin age: 65 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Must habitually complete a minimum of 5000 steps per day * Having obtained informed consent * Non-obese * Non-smoker Exclusion Criteria: * Aged \>80 years * Inability to comply with study procedures * Currently participating or having participated in another infusion trial during last 12 months * Any acute or chronic llness * History of neuromuscular problems * Medications known to affect protein metabolism * Individuals who complete fewer than 5000 steps per day * Individuals who have metal implants

Outcomes

Primary Outcomes

Change in myofibrillar fractional synthetic rate (FSR)

Time frame: one day and 2 weeks

Secondary Outcomes

change in non-myofibrillar fractional synthetic rate (FSR)

Time frame: baseline and one day of feeding

Capillary dilatation and blood flow

Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS)

Time frame: 2 weeks

Data from ClinicalTrials.gov

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