Transcranial direct current stimulation has shown promising results in stroke patients. This study is a double blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. Sixty patients who suffer from chronic strokes will be randomized into 1 of 3 groups: dorsolateral prefrontal cortex, cingulo-opercular network and motor primary cortex (control). Each group will receive transcranial direct current stimulation for 20 minutes for 10 consecutive working days (2 weeks). Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline, after their tenth stimulation session (week 2) and endpoint (week 4). Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
Suellen Andrade
João Pessoa, Paraíba, Brazil
RECRUITINGExecutive Function measured by Dysexecutive Questionnaire (DEX)
Time frame: Change for executive functions at 4 weeks
Verbal Fluency (Semantic Fluency Test)
Time frame: [ Time Frame: Baseline, Week 2 and Week 4 ]
Response inhibition (Go-no-go Test)
Time frame: [ Time Frame: Baseline, Week 2 and Week 4 ]
Executive function (Wechsler Intelligence Scale for Adults)
Time frame: [ Time Frame: Baseline, Week 2 and Week 4 ]
Memory (Rey Auditory Verbal Learning)
Time frame: [ Time Frame: Baseline, Week 2 and Week 4 ]
Processing Speed (Letter Comparison and Pattern Comparison Tasks)
Time frame: [ Time Frame: Baseline, Week 2 and Week 4 ]
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