Early-Phase Safety of Proton Therapy Equipment

Inclusion Criteria: 1. Subjects who are pathologically confirmed to be suffering from solid cancer or brain tumor 2. Subjects who are measurable or with disease that is evaluable 3. Subjects who are expected to survive for at least 90 days 4. Subjects who did not receive any treatment that may affect this treatment (such as PEI, TAE) 4 weeks before they are chosen to receive this treatment 5. ECOG Performance Status (ECOG PS): 0, 1 or 2 6. Patients who can cooperate with the treatment requirements and maintain the gestures required during the irradiation process 7. Patients with well functioning main organs 8. The subject retained main organ functions. 9. The subject age is between 20-75 years old Exclusion Criteria: 1. Subjects who once received radiotherapy on the area planned to be irradiated 2. Subjects whose irradiated area has active or persistent infectious disease 3. Pregnant or possibly pregnant subjects 4. Subjects with other serious complications 5. Subjects who are judged by the Principle Investigator (or co-principle investigator) as unsuitable or because of other reasons described above 6. The subject has the radiotherapy contraindication 7. Breast feeding 8. All the subjects have no plan to conception during the treatment and within one year after treatment 9. Subject who has any electronic devices in the body which could be affected by radiotherapy and has chance to cause accident. For example: pacemaker, artificial heart, brain and spinal cord stimulation, semi-implantable and implantable electrical stimulation、artificial inner ear ...etc