Imaging and Understanding BOS in Lung Transplantation

Children's Hospital Medical Center, Cincinnati6 enrolled

Overview

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.

This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bronchiolitis Obliterans Syndrome

Interventions

Hyperpolarized Helium-3 MRIDRUG

Subjects will inhale Hyperpolarized Helium-3 gas during the MRI. This gas enhances images and the data collected will be used to determine if it can be used to detect BOS earlier than current standard of care.

Eligibility

Sex: ALLMin age: 1 YearMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Lung Transplantation within the last 10 years or being assessed for possible lung transplantation. * Male or female * 0 to 25 years of age. Exclusion Criteria: * Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology * Inability to perform 10 second breath hold for 3He MRI scan * Bleeding disorders

Locations (1)

Children's Hospital Medical Center

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Analysis of MRI imaging to detect BOS compared to biopsy

Time frame: 3 years

Data from ClinicalTrials.gov

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