The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.
Forty patients with systolic heart failure and subclinical hypothyroidism will be include in a open label trial. They will receive levothyroxine supplementation to determine if their functional class will be affect.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
T4 supplementation for heart failure patients with subclinical hypothyroidism.
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
RECRUITINGPerformance at the 6 minutes walk test
Time frame: 6 months
Difference of the brain natriuretic peptide measurement
Time frame: 6 months
Difference of activin a measurement
Time frame: 6 months
Difference of myostatin measurement
Time frame: 6 months
Increase in heart rate measurement
Absence / Presence of tachycardia (heart rate \> 100 beat per minute) at baseline and 6 months
Time frame: 6 months
Difference of systolic and diastolic function on transthoracic echocardiogram
Time frame: 6 months
Arhythmic (ventricular arrhythmias and supraventricular arrythmias) and ischemic events (myocardial infarction, unstable angina and hospitalization for revascularization)
Time frame: 6 months
Normalisation of thyroid workup
Time frame: 6 months
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