"GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy

University of Aarhus128 enrolled

Overview

Patients suffering a stroke with a large vessel occlusion is often treated intra veneous thrombolyse and on top of that also intra arterial therapy. It is unknown what form of anaestesia is best during intra arterial therapy. The investigators will randomize these patients between general anaestesia and local anaestesia. Outcome will be growth of the ischemic lesion as judged on an MRI scan.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

128

Conditions

Stroke Anesthesia Cerebral Revascularization

Interventions

Local anesthesiaPROCEDURE

Conscious sedation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * NIHSS\>10 * mRS=\<2 * groin puncture\<6hours from stroke onset * occlusion of ICA, ICA-T, M1, M2 Exclusion Criteria: * MRI contraindications * GCS\<9 * intubated prior to arrival * posterior circulation stroke * allergy to anestetics

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Growth of DWI lesion

Time frame: 48-72 hours

Secondary Outcomes

Time from arrival to groin puncture and recanalization

Time frame: 1-2 hours

Blood pressure during intervention

Time frame: 1-2 hours

Modified Rankin Score

Time frame: 90 days

Data from ClinicalTrials.gov

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