Infectious complications are responsible for most of deaths in acute pancreatitis.Intestinal barrier dysfunction and increased intestinal permeability was associated with bacterial translocation which is believed to prompted these infections.The purpose of this clinical trail is to observe the potential capability of FMT in reduce the bacterial translocation and alleviate infectious complications by the reconstruction of a gut functional state.
Investigators aims to restore the intestinal bacteria homeostasis through FMT by retention enema with fresh bacteria,thus minimizing bacterial translocation and alleviating infectious complications. The investigators will further examine the effect of FMT on the incidence of infectious complications，duration of clinical course and mortality.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
FMT by retention enema with fresh bacteria from healthy donor
the traditional treatments according to associated guidelines
the First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
RECRUITINGThe control of infectious complications
The temperature recovered to normal for 3 days. The inflammatory cytokines decreased to the normal value.
Time frame: From admission to discharge
C-reactive protein（CRP）level
C-reactive protein (CRP) is a inflammatory prognostic marker
Time frame: 1day before intervention，7days and 14days after intervention
Procalcitionin（PCT）level
Procalcitionin（PCT）level is a inflammatory prognostic marker
Time frame: 1day before intervention，7days and 14days after intervention
Length of Intensive care time and hospital stay
The time of stay in the intensive care unit and hospital
Time frame: From admission to discharge
Mortality
The incidence of death during the time frame
Time frame: From admission to discharge
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.