Assessment of Esophageal Epithelium Integrity With Mucosal Impedance

Vanderbilt University Medical Center15 enrolled

Overview

Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect costs each year upon our healthcare system. Current diagnostic tests for GERD are highly invasive and medically inadequate, and the goal of this project is to develop a novel, minimally invasive Mucosal Impedance technique for more accurate detection of GERD while reducing costs.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Gastroesophageal Reflux Disease (GERD)Non-erosive Reflux Disease (NERD)

Interventions

Standard of Care esophagogastroduodenoscopy (EGD) with mucosal impedance testingPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing standard of care EGD with 48-hr pH testing by BRAVO * Previous diagnosis of reflux * At least 18 years of age Exclusion Criteria: * Those less than 18 years of age * Unable to give informed consent * Use of acid suppressive therapy within the last 10 days * Known history of Barrett's esophagus, gastric surgery, alcoholism, or significant motility condition

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Measurement of lower esophageal impedance using mucosal impedance catheter

Mucosal impedance is obtained during routine care EGD and readings are compared to 48-hour Bravo capsule results. Mucosal impedance only takes one minute to perform during endoscopy.

Time frame: During standard of care EGD

Data from ClinicalTrials.gov

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