Expression of TIM-3 on Lymphocytes in Sepsis

N/AUnknownNCT02319876

Changhai Hospital80 enrolled

Overview

The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its role in immunosuppression during sepsis.

Immunosuppression is the leading cause of death in septic patients.Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of sepsis. Previous studies indicated that T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein and was identified as a marker of lymphocyte dysfunction. The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its further role in immunosuppression during sepsis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis Immunosuppression

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with severe sepsis * patients undergo invasive spine surgery * healthy volunteers Exclusion Criteria: * patients with immunodeficient diseases * patients who accept glucocorticoid or immunosuppressant * patients with an age older than 18 years * patients providing the informed consent

Locations (1)

Anesthesiology and Intensive Care, Changhai Hospital

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

TIM-3 expression on CD4+, CD8+ T cells and CD14+ monocytes

TIM-3 level on T cells was compared between different populations.

Time frame: within 24h after recruitment

Secondary Outcomes

28-day mortality

Time frame: 28 days after diagnosis of sepsis

Central Contacts

Lulong Bo, M.D., Ph.D.

CONTACT

+862131163489 lulongbo@gmail.com

Data from ClinicalTrials.gov

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