Combination Therapy Prevents the Relapse of RA

Inclusion Criteria: * Fulfill 2010 EULAR/ACR RA dignose criteria * Age18-70 years old * Have been teated regularly for 3 months * Disease duration \> 6months * DAS28\>3.2 Exclusion Criteria: * Received surgical operation in 8 weeks * Received other biological agent (eg. rituximab, anti-TNF agents, anti-IL6 agents)in 6 months; * Injection of steroid in 4 weeks * Coexisting with other CTD except for SS * With severe and not controled cardiac vescular disease, neurological disease, pulmonary disease (including COPD and ILD), renal disease, liver disease, endocrine disease and Gastric Intestinal Disease * With not controled diseases including asthma, IBD and psoriasis needing oral or injection of steroid * Active infection with T\>38℃. Patients need admitted into hospital or biotics injection in 4 weeks or need oral biotics in 2 weeks * Malignant history. * Serum creatinine \>130 µmol/L * AST/ALT higher than 2 times upper level * platelet count\<100 x 109/L，or white blood count\<3 x 109/L * Interstitail lung disease: Chest X Ray * Hands X Ray ACR radiology staging shows IV stage RA * Pregnancy or planing to pregnant in 2 years or suckling period women.