Study of Placental Function in Healthy and Pathological Pregnancies

University of Colorado, Denver1,250 enrolled

Overview

The purpose of this study is to establish a tissue and data repository consisting of samples of human placentas, umbilical cord blood, and maternal blood, collected at the time of delivery. Specimens will be used in cellular, molecular, and functional studies to learn more about changes in placental structure and function, which can result in serious pregnancy complications and determine life-long health by programming the fetus for future metabolic and cardiovascular disease.

Study Type

OBSERVATIONAL

Enrollment

1,250

Conditions

Pregnancy

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy women delivering at term * Women with pregnancy complications such as: * pre-term birth, * intrauterine growth restriction, * diabetes, and * obesity. Exclusion Criteria: * Women: * under stress, * experiencing pain of labor. * Pregnancies complicated by other pathologies.

Locations (1)

University of Colorado Hospital

Aurora, Colorado, United States

RECRUITING

Outcomes

Primary Outcomes

Collecting, processing, and archiving human specimens from 1250 subjects

Human placental tissue, umbilical cord blood, and maternal blood samples will be collected from pregnant women at the time of their delivery. The samples will be used to enhance understanding of the role of the placenta in the development of pregnancy complications and in programming of adult disease.

Time frame: Specimens will be stored for 50 years in repository

Central Contacts

Anita Kramer

CONTACT

303-724-1653 anita.kramer@ucdenver.edu

Data from ClinicalTrials.gov

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