The Comparison With Clinical Impacts on Functional Capacity and Symptom Improvement According to the Rhythm Control in Patients With Heart Failure and Recent Onset Atrial Fibrillation

Yonsei University150 enrolled

Overview

Prospective randomized (rhythm control or rate control in heart failure patients with new onset atrial fibrillation) Objective of study 1. To analyze long term outcome of patients with heart failure with new onset atrial fibrillation according to the rhythm control 2. To analyze remodeling of atrium and ventricle by the new onset AF in heart failure patients 3. To analyze the change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

150

Conditions

Heart Failure Recent Onset Atrial Fibrillation

Interventions

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with Heart failure and Atrial fibrillation within 1year (20\~80 years old) 2. LA diameter \< 5mm 3. LVEF 20\~49% 4. patients possible to anticoagulation and anti arrhythmic drug 5. Expected survival \>1yr Exclusion Criteria: 1. Impossible to anticoagulation or anti arrhythmic drug 2. valvular atrial fibrillation ( Mitral valve stenosis, Mitral valve plasty, valve replacement) 3. LV ejection fraction \< 20% 4. Structural cardiac disease 5. Catheter ablation history for AF, maze surgery 6. patient with severe medical disease 7. Impossible to anticoagulation or anti arrhythmic drug

Outcomes

Primary Outcomes

improvement of left ventricular function according to the rhythm control in patient with heart failure and new onset atrial fibrillation

ejection fraction change (echocardiography)

Time frame: 1 year

functional capacity according to the rhythm control in patient with heart failure and new onset atrial fibrillation

peak VO2 (cardio pulmonary test ; CPX)

Time frame: 1 year

Secondary Outcomes

remodeling of atrium by the new onset AF in heart failure patients The change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF

Echo cardiography (LV ejection fraction, LV wall thickness, LV mass index, LA dimension, LA appendage velocity, E/E'), EKG, 24 hours Holter recording

Time frame: 1 years late

remodeling of ventricle by the new onset AF in heart failure patients The change of LV function and functional capacity according to the rhythm in patients with HF and new onset AF