Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

RWTH Aachen University352 enrolled

Overview

The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia.

The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia (stating the date of birth) and second if desflurane is non-inferior in the occurrence of airway complications compared to sevoflurane or total intravenous anesthesia with propofol in the setting of laryngeal mask airway.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

352

Conditions

Anesthesia With Use of LMA (Laryngeal Mask Airway)

Interventions

DesfluraneDRUG

inhalation with laryngeal mask to maintain anaesthesia

SevofluraneDRUG

inhalation with laryngeal mask to maintain anaesthesia

propofolDRUG

intravenous injection to maintain anaesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Planned anesthesia with use of LMA (laryngeal mask airway) * Planned duration of anesthesia between 0.5 and 2 hours * Age between 18-75 years * Both gender * Body mass index (BMI) \<35 * ASA 1-3 * Written informed consent prior to study participation Exclusion Criteria: * Planned additional regional and local anesthesia * Contra-indication for the use of a laryngeal mask airway * Asthma * COPD IV * Known allergy or hypersensitivity to any drugs administered during this study * Women who are pregnant, breast-feeding or women of childbearing potential not using adequate contraceptive methods * Participation in a drug or device trial within the previous 30 days. * Patients legally unable to give written informed consent. * Patients with severe psychiatric disorders * Recent (\<6 months) history of alcohol or drug abuse * Patients with severe neuropsychiatric disorders * Non-fluency in German language

Locations (4)

RWTH Aachen University; Department of Anesthesia

Aachen, Germany

Martha-Maria Hospital Halle Dölau gGmbH, Department of Anesthesia

Halle, Germany

Kreiskliniken Reutlingen, Department of Anesthesia

Reutlingen, Germany

University Hospital Ulm, Department of Anesthesia

Ulm, Germany

Outcomes

Primary Outcomes

time of emergence from anesthesia

time of emergence from anesthesia defined as time between cessation of anesthesia until patient is able to state his/her date of birth on command

Time frame: up to 15 minutes

Secondary Outcomes

Airway reactions (Incidence of intraoperative coughs, laryngospasm)

Incidence of intraoperative coughs (induction/maintenance) - non-inferiority design Incidence of intraoperative laryngospasm (induction/maintenance) Incidence of cough at emergence Incidence of laryngospasms at emergence

Time frame: up to 2 hours

Emergence times

Time to remove laryngeal mask Time to open eyes on command Time to respond on command (press hand) Time to state the name on command Recovery Index (RI = 1 + Aldrete5min/\[(2xextubation time) + 1 x opening eyes time)\]

Time frame: up to 15 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.