A Phase 1, Single and Multiple Dose Study of TAK-137

Inclusion Criteria: * Participant eligibility is determined according to the following criteria prior to entry into the study: * In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements. * The participant signs and dates a written, ICF and any required privacy authorization prior to the initiation of any study procedures. * The participant is a healthy Japanese adult male volunteer. * The participant is between 20 and 45 years of age at the time of informed consent. * The participant has a body weight of at least 50 kg and has a body mass index (BMI) between 18.5 and 24.9 kg/m2 at the time of screening and baseline (Day -1). * A male participant who is sexually active with a female partner of childbearing potential agrees to use adequate contraception after signing the ICF for up to 12 weeks from the last dose. Exclusion Criteria: * Any participant who meets any of the following criteria will not qualify for entry into the study: * The participant has received any investigational drugs within 30 days prior to the first study drug administration. * The participant has received TAK-137 in a previous clinical study. * The participant is an immediate family member, study site employee, or is in a dependant relationship with a study site employee who is involved in the conduct of this study (eg, spouse, parent, child, sibling) or may consent under duress. * The participant has uncontrolled, clinically significant neurologic, cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic or endocrine disease or other abnormality which may impact the ability of the participant to participate or potentially confound the study results. * The participant has previously had a seizure or convulsion (lifetime), including absence seizure and febrile convulsion * The participant has a history of psychiatric disorders. * The participant has a known hypersensitivity to medication(s) or food(s). * The participant has positive results in the urine drug screening test at screening. * The participant has a history of drug abuse (defined as any illicit drug use) or a history of alcohol abuse within 2 years prior to the screening or is unwilling to agree to abstain from alcohol and drugs throughout the study period. * The participant has taken any excluded medication, supplements, or food products listed in the Excluded Medications and Dietary Products during the screening period, or requires such medication or food during the study. * The participant intends to donate sperm from the signing of ICF to 12 weeks after the last dose. * The participant has current or recent (within 6 months) gastrointestinal disease that would be expected to influence the absorption of drugs (i.e., a history of malabsorption, esophageal reflux, peptic ulcer disease, erosive esophagitis, frequent \[more than once per week\] occurrence of heartburn, or any surgical intervention, \[e.g. gastrectomy, cholecystectomy, etc.\]). * The subject has a history of cancer. * The subject has a positive test result for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody/antigen, or serological reactions for syphilis at screening. * The subject has poor peripheral venous access. * The subject has undergone whole blood collection of at least 200 mL within 4 weeks (28 days) or at least 400 mL within 12 weeks (84 days) prior to the first study drug administration. * The participant has undergone whole blood collection of at least 800 mL in total within 52 weeks (364 days) prior to the first study drug administration. * The participant has undergone blood component collection within 2 weeks (14 days) prior to the first study drug administration. * The participant has any clinically significant ECG abnormality at time of screening or baseline (Day -1). * The participant has abnormal screening or baseline (Day -1) laboratory values that suggest a clinically significant underlying disease, or the participant has the following lab abnormalities: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \>1.5 × the upper limits of normal (ULN). * The participant has an abnormal EEG during screening * The participant is at risk for suicide based on the investigator's determination. * The participant who, in the opinion of the investigator, is unlikely to comply with the protocol or is unsuitable for any other reason.