The goal of this clinical trial is to compare the clinical efficacy and safety of IAC regimen and IA regimen as induction chemotherapy for initial diagnosed acute myeloid leukemia (AML) patients. The main question it aims to answer is: •Does IAC regimen higher the complete remission rate in initial diagnosed AML patients? Researchers will compare IAC regimen to IA regimen to see if IAC works to treat AML. Participants will: * Receive IAC or IA as induction regimen * Receive a second cycle of re-induction if partial remission * Visit the clinic once every 3 to 6 months for assessment
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
618
Induction treatment for initially diagnosed AML with IAC regimen, including Cladribine 5mg/msq/d (d1-5), Ara-C 100mg/msq/d(d1-7) and IDA 8mg/msq/d (d1-3)
Induction treatment for initially diagnosed AML with IAC regimen, including Ara-C 100mg/msq/d (d1-7) and IDA 12mg/msq/d (d1-3)
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Complete Remission Rate
complete remission (CR) rate after the induction courses
Time frame: 1-2 months
Overall Survival
2-year overall survival (OS)
Time frame: 2 years
Disease-Free Survival
2-year disease-free survival (DFS)
Time frame: 2 years
Cumulative Incidence of Relapse (CIR)
2-year cumulative incidence of relapse (CIR)
Time frame: 2 years
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