Isolated Anti-HBc Serological Profile in HIV Infected Patients: Immunological, Virological Characteristics and Response to Hepatitis B Vaccination

Inclusion Criteria: * HIV+ adults patients * negative HBsAg * negative a-HBs Ab * positive HBc Ab * without HBV - vaccination * CD4 cell above 200 /mm3 * HIV viral load below 50 copies/mL Exclusion Criteria: * positive HBs antigenemia in the past * transaminitis above fivefold upper normal limit * PT\<50% or Platelet \<50 000/mm3 * ongoing opportunistic infection * ongoing or recent systemic corticoid or immunomodulatory therapy, splenectomy, pregnancy, contra-indication to intramuscular injection, familial history of neurological disease.