BIOD-531 vs. Humalog Mix 75/25 vs. Humulin R U-500 Post-Meal Glucose Control in Patients With Severe Insulin Resistance

Inclusion Criteria: * BMI \> 25 kg/m2 * Diabetes Mellitus using ≥ 150 units of insulin or insulin analog per day and/or ≥ 100 units of insulin or insulin analog at a single dosing session for at least 1 month prior to screening * HbA1c \< 10.0% Exclusion Criteria: * History of bariatric surgery * Corticosteroid therapy * Significant cardiovascular or other major organ disease * Females who are breast feeding or pregnant * A sexually active person not using adequate contraceptive methods