Continuation of Oral ONC201 in Treating Patients With Advanced Solid Tumors

Inclusion Criteria: * Patient has completed participation in one of the ONC201 protocols, has not shown tumor progression while on study treatment, and has tolerated the study drug without unacceptable toxicities * Patient has not met criteria for withdrawal from the base protocol * Patient is willing to comply with protocol requirements and procedures, and keep scheduled study visits * Patient agrees to practice effective contraception during the entire study period unless documentation of infertility exists * Patient is able to understand and is willing to sign the informed consent form Exclusion Criteria: * Patient is receiving concomitant standard and/or investigational anticancer therapy; local palliative radiotherapy is permissible upon discussion with the principal investigator * Patient has alcohol or substance abuse which, in the opinion of the investigator, would interfere with compliance or safety * Patient has any condition or laboratory abnormality which, in the opinion of the investigator, would pose additional risk in administering the study drug to the patient