The main aim is to analyze whether the routine use of chest physiotherapy in non cystic fibrosis bronchiectasis (NCFB) improves the cough severity and the quality of life in this population. In addition, the secondary end-points include incidences of exacerbations, changes in lung function, exercise capacity, airways inflammation, sputum analysis and eventual adverse events.
The present project will be a single-blind , randomized, controlled trial of 12-month daily performing chest physiotherapy compared with usual care, followed by a 3-month intervention-free in non-cystic fibrosis bronchiectasis. Intervention group will perform daily autonomous airway clearance techniques (positive expiratory pressure technique through Acapella device and autogenic drainage technique). Patients will receive professional sessions once a month. Control group will receive their usual care and educational sessions about their disease. Physiotherapist will call them once a month. During the study period the patients' pharmacological treatment remained unchanged
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
26
Subjects will perform daily chest physiotherapy during at least 30 minutes. Patients will perform a slow expiratory airway clearance technique combined with positive expiratory pressure device (Acapella device, Murray et al.) Each patient will receive 12 supervised professional sessions (once a month).
Universidad San Jorge
Zaragoza, Spain
Cough severity (Auto-administered questionnaire: Leicester Cough Questionnaire)
Auto-administered questionnaire: Leicester Cough Questionnaire
Time frame: 1 year
Quality of life (Quality of life-Bronchiectasis questionnaire)
Auto-administered questionaire: Quality of Life- Bronchiectasis
Time frame: 1 year
Exacerbation frequency
Number of exacerbation
Time frame: 1 year
Exercise capacity (Incremental field test: shuttle test)
Incremental field test: shuttle test
Time frame: 1 year
Lung function
Simple spirometry: Forced expiratory volume at 1 second, Forced vital capacity, Forced expiratory flow 25-75
Time frame: 1 year
Airway inflammation as assessed by spontaneous sputum analysis
Inflammatory sputum markers: Myeloperoxidase (MPO) and Cytokines (IL-8)
Time frame: 1 year
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