The Postoperative Analgesic Effect of Combination With Dexmedetomidine in Fentanyl-based Intravenous Patient Controlled Analgesia Compared With Conventional Thoracic Epidural and Intravenous Patient Controlled Analgesia After Radical Open Gastrectomy

Yonsei University171 enrolled

Overview

The aim of this study to test hypothesis that addition of dexmedetomidine to fentanyl based intravenous patient controlled analgesia (PCA) improves postoperative pain compared with conventional thoracic epidural and intravenous patient controlled analgesia after radical open gastrectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

171

Conditions

Postoperative Pain

Interventions

DexmedetomidineDRUG

Dexmedetomidine mixed fentanyl based intravenous PCA

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA class I-II 2. obtaining written informed consent from the parents 3. aged 20-65 years who were undergoing radical open gastrectomy Exclusion Criteria: 1. abdominal surgery previously 2. patient who refuse the patient controlled analgesia 3. unstable angina or congestive heart failure 4. uncontrolled hypertension (diastolic bp\>110mmHg) 5. coagulopathy 6. hepatic failure 7. renal failure 8. bradycardia on EKG (under 50 bpm) 9. Ventricular conduction abnormality 10. drug hyperactivity 11. neurological or psychiatric illnesses 12. mental retardation 13. patients who can't read the consent form due to illiterate or foreigner 14.infection 15\. pregnant 16. obesity (BMI \> 30kg/m2)

Outcomes

Primary Outcomes

Postoperative pain

Postoperative pain measure using verbal numerical rating scales (VNRS) for 48 hrs

Time frame: 48 hours after operation