A Phase I Clinical Trial to Evaluate the Ebola Adenovirus Vector Vaccine (Ad5-EBOV) in Healthy Adults.

Inclusion Criteria: * Aged between 18 and 60 years. * Able to understand the content of informed consent and willing to sign the informed consent * Able and willing to complete all the secluded study process during the whole study follow-up period (about 6 months). * A body mass index (BMI) \<35 * Hemoglobin 110-150g/L for female, and 120-160g/L for male. * White blood cells (WBC) 4.0-10.0×109 cells/L * Total lymphocyte Count 0.8-4.5×109 cells/L * Platelets 100-300×109 cells/L * Alanine aminotransferase (ALT) 0-40U/L * Serum creatinine 44-106μmol/L * Partial thromboplastin time (PTT) 20-40 seconds * Prothrombin time (PT) 10-14 seconds * Negative in HIV diagnostic blood test * Axillary temperature ≤37.0°C on the day of enrollment * General good health as established by medical history and physical examination. Exclusion Criteria: * Family history of seizure, epilepsy, brain or mental disease * Subject that has a medical history of any of the following: allergic history of any vaccination or drugs, or allergic to any ingredient of the Ad5-EBOV vaccine, such as mannitol * Woman who is pregnant, breast-feeding or positive in β-HCG (human chorionic gonadotropin) pregnancy test (urine) on day of enrollment, or become pregnant during the next 6 months * Any acute fever disease or infections in last 7 days * Major congenital defects or not well-controlled chronic illness, such as asthma, diabetes, or thyroid disease * Hereditary angioneurotic edema or acquired angioneurotic edema * Urticaria in last one year * Asplenia or functional asplenia * Platelet disorder or other bleeding disorder may cause injection contraindication * Faint at the sight of blood or needles. * Prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months * Prior administration of blood products in last 4 months * Prior administration of other research medicines in last 1 month * Prior administration of attenuated vaccine in last 1 month * Prior administration of inactivated vaccine in last 14 days * Current anti-tuberculosis prophylaxis or therapy * Any condition that in the opinion of the investigators may interfere with the evaluation of study objectives