The purpose of this study is to evaluate the feasibility, safety and efficiency of zero ischemia laparoscopic microwave ablation-assisted enucleation in comparison with conventional laparoscopic partial nephrectomy in the treatment of T1a renal cell carcinoma.
Microwave ablation has been widely used in the minimally-invasive treatment of renal tumors. Recently, a technique of laparoscopic microwave ablation-assisted renal tumor enucleation was developed, but the experience was preliminary. This study aims to evaluate the feasibility, safety and efficiency of this technique, particularly its role in the preservation of renal function, in comparison with conventional laparoscopic partial nephrectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
183
Renji Hospital
Shanghai, Shanghai Municipality, China
absolute change in glomerular filtration rate (GFR) of the affected kidney
measured by renal scintigraphy
Time frame: baseline, 3 months and 12 months
absolute change in eGFR of the affected kidney
Time frame: baseline, 3 months, 6 months and 12 months
absolute change in total GFR
measured by renal scintigraphy
Time frame: baseline and 6 months
blood loss
Time frame: during surgery
operation time
Time frame: during surgery
surgical margin
assessed according to the pathology report of the operation specimen
Time frame: 1 month
postoperative complications
number of participants with postoperative complications graded by Clavien- Dindo system
Time frame: up to 6 months
progression-free survival
Time frame: 12 months
local recurrence
Time frame: 12 months
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