The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
13
University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Airway response to inhaled allergen
area under forced expiratory volume in one second versus time curve; 0-3hours (early response) and 3-7 hours (late response)
Time frame: at time of allergen inhalation challenge and for 7 hours after
Airway response to inhaled methacholine
delta log methacholine PC20 (provocative concentration of methacholine causing a 20% decrease in the forced expiratory volume in one second)
Time frame: day before allergen inhalation challenge and 8 hours after allergen inhalation challenge
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