Integrated RF and B-mode Deformation Analysis for 4D Stress Echocardiography

Yale University

Overview

The specific aim of this clinical trial is to translate the investigators new 4DE (three sptial dimensions pluse time) stress echocardiographic method to patients with coronary artery disease referred for clinically indicated dobutamine stress/rest echo to evaluate the reproducibility of the technique in this clinical setting.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Coronary Artery Disease

Interventions

Stress Dobutamine Echocardiographic using 4DE SystemPROCEDURE

Subjects will undergo their clinically indicated stress dobutamine echocardiographic studies using our standard clinical graded dobutamine stress imaging protcol, employing the iE33 4DE system.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * At least 18 years of age, referred for clinically indicated dobutamine rest/stress TTE * Provide written informed consent to participate in the study * Availability for repease rest/stress TTE within on eweek of clinically indicated study Exclusion Criteria: * Unable to give informed consent * Unstable hemodynamics that would not allow for repease rest/stress dobutamine transthoracic imaging * Recurrent life threatening arrhythmias * Heart rate \>110 BPM * Inadequate windows for transthoracic imagine * Patients that have a narrow-angle glaucoma (contraindication for atropine) * Change in cardiac medications or management including, coronary revascularization beween intial and repeat TTE study.

Outcomes

Primary Outcomes

Number of Subjects With an Interpretable 4DE Image

This outcome will measure feasibility. Data from images will be analyzed with the integrated speckle/shape tracking approach (the method uses boundary detection/shape tracking to quantify left ventricular myocardial deformation)

Time frame: After Stress Echocardiography (Approximately 2 hours)

Data from ClinicalTrials.gov

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