Renal Denervation in Patients With Chronic Heart Failure and Resynchronization Therapy

Inclusion Criteria: 1. age ≥ 18 year 2. heart failure patients NYHA Class II - IV 3. implanted resynchronization pacemaker according to current european guidelines at least 6 months earlier 4. symptoms of heart failure even on optimal pharmacological therapy including resynchronization therapy (lack of improvement within dyspnoea and exercise tolerance after the procedure) 5. left ventricular ejection function ≤ 35% 6. glomerular filtration rate (eGFR according to MDRD formula ≥ 30 mL/min/1.73m2) 7. patient informed consent for participation in the study Exclusion Criteria: 1. renal artery anatomy not eligible for denervation (at least 4 mm diameter, 20 mm in length) 2. history of prior renal artery intervention 3. single functioning kidney 4. clinic systolic BP \< 110mmHg 5. pregnancy 6. acute coronary syndrome or cerebrovascular event within last 3 months 7. serious medical conditions which may adversely affect safety- clinically significant peripheral vascular disease, abdominal aortic aneurysm, bleeding disorders (thrombocytopenia, hemophilia, or significant anemia)