Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION

Second Military Medical University60 enrolled

Overview

NAION produces an ischemic insult in the optic nerve head presumably due to the hypoperfusion of the short ciliary arteries that supply it. Intravenous injection of glucocorticoid have proven to be effective in treatment of Nonarteritic Anterior Ischemic Optic Neuropathy,but have some side effects. the investigators believe that offering them Retrobulbar Triamcinolone Acetonide Injection that might halt the progression of the visual acuity and visual field loss if our hypothesis is correct, would greatly improve their chances of avoiding blindness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Triamcinolone Acetonide Optic Neuropathy, Ischemic

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: Sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn (\<30 days) Exclusion Criteria: Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy) Neurologic defect Abnormal ESR, CRP, any history of retina or vitreal surgery Severe corneal opacity which makes retina examination impossible

Outcomes

Primary Outcomes

Changes of Best corrected visual acuity(BCVA)

Time frame: baseline and 1month, 3month

Secondary Outcomes

Changes of Visual Field