Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers

Next Gen Pharma India Pvt. Ltd.60 enrolled

Overview

Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species. The periodontal destruction is substantially mediated by the host, driven by the bacterial challenge. The presence of pathogenic bacteria with the absence of so-called "beneficial bacteria" and the susceptibility of the host are the main aetiological factors of periodontal diseases.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Periodontitis

Interventions

Lactobacillus brevis CD2 LozengesDRUG

Each lozenge contains not less than 1 billion Colony forming unit of Lactobacillus brevis CD2

Eligibility

Sex: ALLMin age: 30 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients free from any systemic illness * Previously untreated moderate to severe generalised chronic periodontitis. * Patients free from adverse reactions to lactose or fermented milk products * Patient unwilling to quit smoking and smokers over the past one year ( Smoker arm). Exclusion Criteria: * Previous history of antibiotic usage over past 6 months * Patients who are eligible for antibiotic usage during the treatment course * Patients who are pregnant, lactating, alcoholic or who had undergone any surgical or nonsurgical therapy within 6 months. * Acute oral lesions or necrotising ulcerative periodontitis

Locations (1)

Krishnadevaraya College of Dental Sciences and Hospital

Bangalore, Karnataka, India

Outcomes

Primary Outcomes

Improvement in Clinical Periodontal Indices

Improvement in clinical periodontal indices, namely, Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD)

Time frame: 8 weeks

Secondary Outcomes

Change in microbiological indices

Porphyromonas gingivalis, Tanerella forsythus

Time frame: 8 weeks

Data from ClinicalTrials.gov

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