Surgical stress creates a state of insulin resistance which has been related to increased postoperative complications. Fasting before surgery induces a catabolic state that contributes to the development of insulin resistance. The aim of this study is to evaluate the effect of preoperative oral carbohydrates on postoperative insulin resistance in patients undergoing OPCAB (off-pump coronary artery bypass surgery). Sixty patients, aged 20 to 79 years, scheduled for OPCAB will be divided into carbohydrate (n=30) and control (n=30) groups. Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before surgery and in the morning of the operation day (3 hours before their scheduled operation). In contrast, patients in the control group consume no food or drink after midnight before their surgery. The primary endpoints are postoperative insulin resistance measured by short insulin tolerance test.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
57
400ml of 12.8 g/100 ml carbohydrate beverage
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, Seoul, South Korea
postoperative insulin resistance
Time frame: within 1 hour after surgery
preoperative discomfort
the preoperative discomfort measured by VAS (Visual Analog Scale)
Time frame: 24 hours
perioperative hemodynamic effect
perioperative hemodynamic effect measured by amount of used vasopressors and minimum mixed venous oxygen saturation
Time frame: 24 hours
postoperative complications
infection, Myocardiac infarction, Acute renal failure, re-operation, death, etc
Time frame: 24 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.