Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

Inclusion Criteria: * Diagnosis of lung cancer, pancreatic cancer or cholangiocarcinoma where the diagnosis is based on histological, radiological or multidisciplinary team (MDT) evaluation * non-small cell lung cancer (stage III or IV), pancreatic adenocarcinoma (stage III or IV), due to commence first or second line anticancer treatment (defined as chemotherapy, chemo-radiotherapy, targeted therapy or immunotherapy) * staging CT within 4 weeks of commencement of anti-cancer therapy (in patients where staging CT is out-with this period, further CT scanning will be undertaken. PETCT's are also appropriate) * completed all other baseline assessments within one week prior to first course of anti-cancer treatment * written informed consent * able to comply with trial interventions (in the opinion of referring clinician) e.g. willing and able to do light exercise and take oral nutritional supplements as well as no major contraindications against ibuprofen. * Karnofsky Performance Status \>70 Exclusion Criteria: * Neuro-endocrine pancreatic cancer * Creatinine clearance \<30ml/min * Receiving parenteral nutrition or enteral nutrition via feeding tube * receiving neo-adjuvant anti-cancer therapy * BMI \>30 kg/m2 * Use of appetite stimulants or anabolic/anti-catabolic agents (such as megestrol acetate, progestational agents, marijuana growth hormone, dronabinol, or other anabolic agent) within 30 days prior to study baseline * Concomitant steroid (\>10mg/d prednisolone or equivalent) treatment for less than three months prior to inclusion (inhaled, optical or pulsed oral steroids (up to 10 days use) are permitted) * Concomitant long term (\>1 week) nonsteroidal anti-inflammatory drugs (NSAID) or aspirin treatment * pregnancy, breast-feeding or of child bearing potential (that is not postmenopausal or permanently sterilised) age and not using adequate contraception (oral, injected, implanted or hormonal methods of contraception, intrauterine device and barrier method) * Concomitant anti-coagulant treatment (e.g. warfarin or heparin)