Esophageal Motility in eosinophilic esophagitis will be evaluated by High Resolution Manometry before and after medical treatment - motility is suspected to change/improve after therapy.
After identification of eosinophilic inflammation of the esophagus -\> differentiation between GERD and eosinophilic esophagitis (via pH/MII-measurements or PPI-trial) -\> High-resolution manometry (HRM) for evaluation of esophageal motility in patients with eosinophilic esophagitis (exclusion of GERD-patients)-\> initiation of budesonide-therapy -\> after eight weeks of therapy reevaluation of esophageal motility by HRM
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
20
High resolution manometry of the esophagus
Klinikum rechts der Isar, II. Medizinische Klinik
München, Germany
RECRUITINGImprovement of esophageal motility (IBP) measureable in high resolution manometry (HRM)
Average maximum intra-bolus-pressure (IBP) \[mmHg\] before and after therapy
Time frame: Two months
Improvement of esophageal motility (e.g. specified in the chicago classification) represented in high resolution manometry (HRM)
weak peristalsis with small/large breaks, frequently failes peristalsis, absent peristalsis, hypertensive peristalsis, rapid contractions with normal latency, functional EGJ-obstruction, panesophageal pressurizations, compartimentalized pressurizations;
Time frame: Two months
Endoscopic evaluation of inflammation before/after therapy
Endoscopic assessment of esophageal signs of eosinophilic esophagitis (white exsudates, furrows, edema, rings, crepe paper, stricture
Time frame: Two months
Symptoms before/after therapy
Evaluation of symptoms via questionnaire before/after therapy
Time frame: Two months
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