Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetine

Inclusion Criteria: * The patient is a man or woman, aged ≥18 years and \<65 years (In the province of British Columbia, the patient must be aged 19 years or older in order to give Informed Consent) * The patient is engaged in volunteer work or gainful employment (working ≥20 hours per week) or is enrolled full-time in post-secondary studies or vocational training. * The patient is an outpatient consulting a Primary Care Physician or a Psychiatrist. * Patients must have a diagnosis of MDD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5™) classification code 296.3x. * The current MDE is confirmed by the investigator. * The reported duration of the current MDE is at least 3 months. * The patient has a Baseline score ≥15 on the QIDS-SR. * The patient reports at least a minimal level of cognitive symptoms as defined by Baseline score of ≥30 on the PDQ-D-20. * The patient is capable of communicating with the site personnel and is able to conduct the digit-symbol substitution test (DSST). Exclusion Criteria: * The patient score is \>69 on the DSST at Screening/Baseline. * The patient is, in the opinion of the investigator, not able to complete all the study assessments including, but not limited to, patient-reported assessments and the DSST. * The patient has a current diagnosis or history of manic or hypomanic episode, schizophrenia or any other psychotic disorder, including major depression with psychotic features. * The current depressive symptoms are considered by the investigator to have been resistant to 2 adequate antidepressant treatments of at least 6 weeks duration each at the maximum recommended dose (according to Canadian labeling). Other protocol defined inclusion and exclusion criteria do apply.