Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.

Inclusion Criteria: * Patient informed about the study * Patients aged at least 18 years admitted to a medical Intensive Care or general intensive care * Patients with suspected invasive candidiasis - that is to say: * Presenting persistent sepsis despite broad-spectrum antibiotherapy for at least 48 hours or targeted antibiotherapy for a documented bacterial infection (sepsis will be defined according to: * the usual SIRS criteria, at least 2 of the following 4: temperature \> 38°C or \< 36°C, tachycardia \> 90/min, respiratory rate \> 20/min or blood pressure carbon dioxide (PaCO2 ) \< 32 mmHg, leukocytosis \> 12000/mm3 or \< 4000/mm3 or \> 10% of immature forms. * Persistent hemodynamic instability (impossibility to significantly diminish catecholamine requirement, need for rapid vascular resuscitation \> 1000 ml over the previous 24 hours) * Candida score ≥ 3 with multifocal colonization * Decision to initiate echinocandin therapy made by the clinician in charge of the patient Exclusion Criteria: * Treatment with echinocandin \> 1 day in the week preceding inclusion * Patients not covered by national health insurance * Pregnant or breast-feeding women