Proportion of circulating tumor cells (CTC) in the postoperative phase after curative tumor removal of pancreatic cancer will be determined and correlated to the accordance of anesthesia (desflurane versus propofol)
This prospective, randomized study will be conducted over a 36-month period to investigate whether commonly used anesthetics (volatile versus intravenous) have an effect on the changes or occurrence of CTC in patients suffering from primary pancreatic cancer undergoing curative surgery. The specific research question is if there are changes of the CTC count in the postoperative phase in the desflurane group (intervention) compared to the propofol one (control). A secondary question is if these changes can be correlated to tumor outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
86
Apply desflurane as anesthetic
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Kantonsspital Winterthur
Winterthur, Switzerland
Stadtspital Triemli
Zurich, Switzerland
University Hospital Zurich
Zurich, Switzerland
Peak of CTC in the postoperative phase after curative tumor removal
CTC will be counted and peak of CTC will be determined.
Time frame: Day 0 to Day 7
Kinetics of CTC after surgery up to day 7
CTC will be counted and kinetics of CTC will be determined.
Time frame: 1 year
Month to Tumor recurrence
Tumor recurrence will be monitored.
Time frame: 1 year
Number of surviving patients
One year after surgery the number of patients still being alive will be determined.
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.