Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis

General Hospital of Shenyang Military Region475 enrolled

Overview

The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate. Considering that PVT potentially elevates the portal pressure and thereby increase the risk of variceal bleeding, we focus on the patients with high-risk varices and variceal bleeding as the study population. Thus, the main goals are to analyze the effect of PVT on the incidence of first variceal bleeding in patients without any prior bleeding history but with high-risk varices, the incidence of recurrent variceal bleeding in patients with a history of variceal bleeding, and the treatment failure rate of variceal bleeding in patients with acute variceal bleeding. Certainly, the survival is also observed in all patients.

Study Type

OBSERVATIONAL

Enrollment

475

Conditions

Liver Cirrhosis Portal Vein Venous Thrombosis Varicose Veins Hemorrhage

Interventions

Endoscopic sclerotherapy, endoscopic variceal ligation, endoscopic tissue glue injectionPROCEDURE

Endoscopic sclerotherapy, endoscopic variceal ligation, and/or endoscopic tissue glue injection will be performed based on the endoscopists' choice.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. A diagnosis of liver cirrhosis. 2. Patients should be diagnosed with high-risk varices endoscopically, or a prior history of variceal bleeding, or an episode of acute variceal bleeding. 3. Patients agreed to undergo endoscopy to evaluate the presence and severity of varices. 4. Patients agreed to undergo contrast-enhanced CT scans to evaluate the portal vein patency. But if an abdominal contrast-enhanced CT scans was performed within 3 months after admission, it was not necessarily repeated. Exclusion Criteria: 1. Non-cirrhotic patients. 2. Malignancy. 3. Contrast-enhanced CT scans were neither feasible nor available. 4. Severe cardiopulmonary diseases. 5. Severe infectious diseases. 6. Pregnant or breastfeeding. 7. Allergic to contrast agents. 8. Poor adherence.

Outcomes

Primary Outcomes

Overall survival

Time frame: 6-24 months

First bleeding

As for the patients without any prior history of bleeding but with high-risk varices, the first bleeding was observed.

Time frame: 0-24 months

Recurrent bleeding

As for the patients with a prior history of bleeding, the recurrent bleeding was observed.

Time frame: 0-24 months

Treatment failure rate of acute variceal bleeding

As for the patients with acute variceal bleeding, the 5-day treatment failure of acute bleeding was observed.

Time frame: 5 days