Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder

Bakirkoy Dr. Sadi Konuk Research and Training Hospital90 enrolled

Overview

Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.

Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia. Infection or other obvious causes must be excluded. The overactive bladder is loss of inhibition of the detrusor muscle during the filling or emptying of the bladder. Specific receptors and neurotransmitters have role in development of overactive bladder. These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and interstitial cells. Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder. The investigators believe that our findings will shed light on treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Overactive Bladder

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women with urgency, nocturia and frequency * Abdominal obesity, defined as a waist circumference in men ≥88 cm * Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides * Serum HDL cholesterol \<40 mg/dL (1 mmol/L) in men and \<50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C * Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure * Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose Exclusion Criteria: * Chronic obstructive pulmonary disease allergy * Psychiatric disorders * Urinary tract infection * Neurological diseases * Metabolic diseases * Pure stress or mixed urinary incontinence * History of pelvic surgery * Diabetes mellitus

Locations (1)

Bakirkoy Dr Sadi Konuk Training and Research Hospital

Istanbul, Bakirkoy, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

nerve growth factor levels

association between nerve growth factor levels and overactive bladder

Time frame: 3 months

Secondary Outcomes

urge incontinence

number of urge incontinence

Time frame: 3 months

overactive bladder symptoms

number of nocturia,urgency,frequency

Time frame: 3 months

Data from ClinicalTrials.gov

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