Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass Surgery

Hvidovre University Hospital12 enrolled

Overview

The aim of this study is to examine the effect of GLP-1 and other gut-secreted hormones (glucagon, GIP, grelin and PYY) on food-intake, appetite and glucose metabolism after Roux-en-Y gastric bypass surgery.

To do this the effect of combined GLP-1 receptor blockade by Exendin 9-39 and DPP-4-inhibition will be evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Severe Obesity

Interventions

exendin 9-39DRUG

Exendin 9-39 is a specific GLP-1 receptor antagonist

sitagliptinDRUG

DPP-4 Inhibition

PlaceboOTHER

Saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Uncomplicated RYGB performed 3-12 month proir to the study. Fasting plasma glucose \<7.0 mM and HbA1c \< 48 mmol/mol 3 month after RYGB. Exclusion Criteria: * Fasting plasma glucose \>7.0 mM and HbA1c \> 48 mmol/mol 3 month after RYGB. Hemoglobin \<6.5mM. Previous anaphylaxis when treated with Januvia or Byetta. Allergy for sitagliptin. Dysregulated hypothyroidism. Use of antithyroid treatment. Late diabetic complications as retinopathy, renal insuffiency, neuropathy or previous pancreatitis. Bad compliance. * Complications to RYGB: Documented reactive hypoglycaemia, severe dumping (with vomiting, diarrhea or severe abdominal pain after food intake).

Locations (1)

Hvidovre University Hospital

Hvidovre, Denmark

Outcomes

Primary Outcomes

Ad libitum food intake (changes in food intake)

Evaluated by changes in food intake between the placebo day and the day with both administration of exendin 9-39 and DPP 4 Inhibitor

Time frame: 3-12 month after RYGB

Secondary Outcomes

Glucose metabolism (iAUC of glucose and c-pep after a meal)

Evaluated by iAUC of glucose and c-pep after a meal

Time frame: 3-12 month after RYGB

Gut-derived hormone profiles (iAUC of GLP-1, PYY, GIP and glucagon after a meal)

Evaluated by iAUC of GLP-1, PYY, GIP and glucagon after a meal

Time frame: 3-12 month after RYGB

Appetite measurement (VAS-scores)

Evaluated by VAS-scores

Time frame: 3-12 month after RYGB

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.