Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx

Inclusion Criteria: * Patients older than 18 years * Patients with squamous cell carcinoma of the oropharynx, HPV-negative (p16 assay) * T size of 3 cm or more in greatest dimension with the exclusion of tumor with bone infiltration * N0, N1, N2a, N2b node (AJCC/UICC 7th edition) * No distant metastasis * No contra-indication to concomitant chemotherapy * World Health Organization (WHO) Performance Status of 0 or 1 or Karnofsky performance status ≥ 80. * Provision of written informed consent Exclusion Criteria: * Patients with induction chemotherapy will not be eligible * Previous or concurrent history of cancer, except basal cell skin carcinoma * Second primary tumor at the time of diagnosis * Previous treatment with surgery, radiotherapy or chemotherapy for head and neck malignancy * Any evidence of severe or uncontrolled systemic diseases (e.g., unstable or uncompensated respiratory, cardiac, hepatic or renal disease), or psychological disorder * Pregnant or lactating women