To compare the nutritional effect on blood glucose of two commercially available enteral diets in overweight or obese patients in the Intensive Care Unit.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
106
Commercially available enteral diet
Commercially available enteral diet
Emory University Hospital
Atlanta, Georgia, United States
University of Chicago Medicine
Chicago, Illinois, United States
University of Kentucky Albert B. Chandler Hospital
Lexington, Kentucky, United States
Regions Hospital
Saint Paul, Minnesota, United States
Glucose variability - Number of glycemic events outside the serum glucose range of 110-150 mg/dl
Number of glycemic events outside the serum glucose range of 110-150 mg/dl
Time frame: First seven days in the ICU
Glucose variability - Number of glycemic events between 80-110 mg/dl and 150-180 mg/dl
Number of glycemic events between 80-110 mg/dl and 150-180 mg/dl
Time frame: First seven days in the ICU
Glucose variability - Number of episodes of hypoglycemia (glucose < 80 mg/dl)
Number of episodes of hypoglycemia (glucose \< 80 mg/dl)
Time frame: First seven days in the ICU
Glucose variability - Number of episodes of hyperglycemia (glucose > 180 mg/dl)
Number of episodes of hyperglycemia (glucose \> 180 mg/dl)
Time frame: First seven days in the ICU
Glucose variability - Average glucose levels
Average glucose levels
Time frame: First seven days in the ICU
Need for exogenous insulin administration
Number of administrations, amount of insulin received, number of times insulin order adjusted, circulating C-peptide at baseline, day 3, 5 and 7
Time frame: First seven days in the ICU
Need for exogenous glucose administration
Number of times of administration and amount of glucose received
Time frame: First seven days in the ICU
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Queen's University
Kingston, Ontario, Canada
Nursing time
Time required to monitor glucose levels and adjust insulin regimens in subset of patients studied
Time frame: First seven days in the ICU