Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Inclusion Criteria: * Diagnosis of open-angle glaucoma or ocular hypertension insufficiently controlled on monotherapy or currently on multiple IOP-lowering medications; * Mean IOP measurements within guidelines specified in the protocol. Must not be \> 36 mmHg at any time point; * Able to understand and sign an informed consent form; * Other protocol-specified inclusion criteria may apply. Exclusion Criteria: * Women of childbearing potential who are pregnant, test positive for pregnancy, intend to become pregnant during the study period, breast-feeding, or not in agreement to use adequate birth control methods throughout the study; * Severe central visual field loss in either eye; * Unable to safely discontinue all IOP-lowering ocular medication(s) for a minimum of 5 (± 1) to 28 (± 1) days prior to E1 Visit; * Chronic, recurrent or severe inflammatory eye disease; * Ocular trauma within the past 6 months; * Ocular infection or ocular inflammation within the past 3 months; * Clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy, or retinal detachment; * Best-corrected visual acuity (BCVA) score worse than 55 ETDRS letters (equivalent to approximately 0.60 logMAR, 20/80 Snellen, or 0.25 decimal); * Other ocular pathology (including severe dry eye) that may preclude the administration of α-adrenergic agonist and/or topical carbonic anhydrase inhibitor (CAI); * Intraocular surgery within the past 6 months; * Ocular laser surgery within the past 3 months; * Any abnormality preventing reliable applanation tonometry; * Any conditions including severe illness which would make the Subject, in the opinion of the Investigator, unsuitable for the study; * History of active, severe, unstable or uncontrolled cardiovascular, cerebrovascular, hepatic, or renal disease that would preclude safe administration of a topical α-adrenergic agonist or CAI; * Recent (within 4 weeks of the E1 Visit) use of high-dose (\> 1 g daily) salicylate therapy; * Current or anticipated treatment with any psychotropic drugs that augment adrenergic response (eg, desipramine, amitriptyline); * Concurrent use of monoamine oxidase inhibitors (MAOI); * Concurrent use of glucocorticoids administered by any route; * Therapy with another investigational agent within 30 days prior to the Screening Visit; * Hypersensitivity to α-adrenergic agonist drugs, topical or oral CAIs, sulfonamide derivatives, or to any component of the study medications; * Less than 30 days stable dosing regimen before the Screening Visit of any medications (excluding IOP-lowering treatments) or substances administered by any route and used on a chronic basis that may affect IOP, including but not limited to β-adrenergic blocking agents; * Use of any additional topical or systemic ocular hypotensive medication during the study; * Other protocol-specified exclusion criteria may apply.