Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration

Saint John's Cancer Institute27 enrolled

Overview

Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration Lymphocytes (TIL)

The purpose of this study is to allow the collection of tissue from subjects to be used in future research studies by scientists and to isolate tumor fighting cells for the future treatment of Melanoma.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Melanoma

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients must have metastatic melanoma with a resectable metastasis who are undergoing resection for palliation, therapeutic or curative purpose. 2. Patients must be \> 15 years of age and must have metastatic melanoma. 3. Patients must meet standard pre-operative requirements as determined by the surgeon to be candidates for surgery. 4. Patients must be able to understand and sign the Informed Consent document. 5. Patients must be able to complete the supplemental data form Exclusion Criteria: 1. women who are pregnant or breastfeeding 2. inability to give consent

Locations (1)

John Wayne Cancer Institute

Santa Monica, California, United States

Outcomes

Primary Outcomes

Evaluate Feasibility of conducting TIL procurement in a single-site setting

Cell viability, viable number and TIL potency using standardized methods

Time frame: 5 years

Evaluate Safety of conducting TIL procurement in a single-site setting

lab personnel training during procurement, isolation, testing tumor reactivity and cryopreservation

Time frame: 5 separate TIL procedures

Secondary Outcomes

To determine whether TIL Procurement, isolation, testing tumor reactivity and cryopreservation can be performed at John Wayne Cancer Institute (JWCI) and Providence Saint John's Health Center (PSJHC) and infused into patients

Time frame: 5 years

Data from ClinicalTrials.gov

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